13 CO 2 breath tests in non-invasive hepatological diagnosis
نویسندگان
چکیده
منابع مشابه
13CO2 breath tests in non-invasive hepatological diagnosis
In liver diagnostics, a simple, non-invasive test with high sensitivity and specificity is permanently being sought in order to assess the degree of liver damage. In addition to liver biopsy, algorithms using blood parameters or elastometry are used in clinical practice. However, these methods do not provide information about the true liver reserve, so the liver breath test seem to be a promisi...
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Breath tests allow a non-invasive and fast diagnostic of different specific enzymes' phenotypic functionality. Over the last decade several 13C-breath tests were successfully tested, with the (13)C-urea breath test being approved by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). The use of other targets than labeled (13)CO2 in exhaled breath offers additional...
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Breath tests have in common the fact the subject is given a substrate in which C atoms normally present in the functional group are replaced by the stable isotope C. This functional group is cleaved enzymatically under specific circumstances, during either transit through the gastrointestinal tract, absorption, or further metabolism of the absorbed substrate. After cleavage, the labeled subgrou...
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Non-invasive breath tests can serve as valuable diagnostic tools in medicine as they can determine particular enzymatic and metabolic functions in vivo. However, methodological pitfalls have limited the actual clinical application of those tests till today. A major challenge of non-invasive breath tests has remained the provision of individually reliable test results. To overcome these limitati...
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ژورنال
عنوان ژورنال: Gastroenterology Review
سال: 2015
ISSN: 1895-5770
DOI: 10.5114/pg.2014.47501